Summary: Identification of selective Metal Garden Stake deubiquitinase (DUB) inhibitors is critical for probe development to further understand and explore DUB biological function.Here, we detail the optimization and deployment of an in vitro fluorogenic ubiquitin-rhodamine assay to conduct high-throughput screening of a small molecule library agai
Kinesin motors are a large family of molecular motors that walk along microtubules to fulfill many roles in intracellular transport, microtubule organization, and chromosome alignment.Kinesin-7 CENP-E (Centromere protein E) Winter Sports - Soft Goods - Jackets is a chromosome scaffold-associated protein that is located in the corona layer of centro
Abstract Background To understand the evolution of animals it is essential to have taxon sampling across a representative spread of the animal kingdom.With the recent rearrangement of most of the Bilateria into three major clades (Ecdysozoa, Lophotrochozoa and Deuterostomia) it has become clear that the Lophotrochozoa are relatively poorly represen
Abstract Massive boulders in landslide and tsunami deposits are prominent geomorphic features in various landscapes.Tracking their movement history is important for reconstructing past geologic dynamics; however, the reworking movements of massive boulders remain unresolved.The boulder field on the Ishigaki Island was formed by repeated tsunamis.Al
Abstract Visual systems have evolved to discriminate between different wavelengths of light.The ability to perceive color, or specific light wavelengths, is important as color conveys crucial information about both biotic and abiotic features in the environment.Indeed, different wavelengths of light can drive distinct patterns of activity in the ve